From Donor to Recipient: The Science of Restarting a Silent Heart
How do you bring a heart back to life after it has stopped beating? In Toronto, scientists and surgeons have turned that question into a life-saving reality.
The Challenge
When the heart stops, blood flow and oxygen drop fast. Within minutes, tissue damage can occur. That’s why most transplant programs have relied on “beating” hearts — they’re easier to keep healthy. But with technology improving, doctors have found ways to safely restart and test non-beating hearts before transplant.
The Science Behind It
The key tool is the Organ Care System (OCS) — a portable “heart box” that mimics the human body. Once the donor heart is retrieved, it’s connected to this machine, which pumps warm, oxygenated blood through it. Monitors measure heart rate, pressure, and function to confirm the organ’s readiness.
If the heart performs well, it’s green-lit for transplantation. The machine also allows more time — sometimes up to six hours — for transport and preparation.
A Canadian First
In September 2025, the team at UHN’s Ajmera Transplant Centre used this approach successfully. It was Canada’s first non-beating heart transplant and a major scientific milestone. Other countries, including the UK and the US, have been using DCD heart transplants for a few years, showing excellent survival rates.
Why It’s Hopeful
This innovation means:
More donors — people who previously couldn’t donate can now help others.
Shorter waitlists — more hearts available for transplant.
Better outcomes — the heart’s function can be tested before surgery.
It’s science and compassion working hand-in-hand. By learning how to restart a silent heart, Canada’s medical teams are giving hope — and new heartbeats — to those who need them most.
